Lesson 11Adaptive Immunity“Specific Immunity”
... • These stem cells migrate to the thymus where they mature into T cells – Thymic selection eliminates many immature T cells • Similar to clonal deletion of B cells. Weed out cells that would otherwise attack “self” ...
... • These stem cells migrate to the thymus where they mature into T cells – Thymic selection eliminates many immature T cells • Similar to clonal deletion of B cells. Weed out cells that would otherwise attack “self” ...
Bio-261-Immune-System-part-2
... target cells, leading to fragmentation of the nucleus, release of small apoptotic bodies, and eventual cell death. The released cytotoxic T cell can attack other target cells. ...
... target cells, leading to fragmentation of the nucleus, release of small apoptotic bodies, and eventual cell death. The released cytotoxic T cell can attack other target cells. ...
Document
... Phagocytosis is a specific form of endocytosis by which cells internalise solid matter, including microbial pathogens. While most cells are capable of phagocytosis, it is the professional phagocytes of the immune system, including macrophages, neutrophils and immature dendritic cells, that truly exc ...
... Phagocytosis is a specific form of endocytosis by which cells internalise solid matter, including microbial pathogens. While most cells are capable of phagocytosis, it is the professional phagocytes of the immune system, including macrophages, neutrophils and immature dendritic cells, that truly exc ...
No Slide Title
... PRESENTING CELL BY ENDOCYTOSIS • DIGEST IN PHAGOLYSOSOME • FRAGMENTS COMBINE WITH PREFORMED MHC CLASS II • DISPLAYED ON PLASMA MEMBRANE • RECOGNIZED BY CD4 + CELLS ...
... PRESENTING CELL BY ENDOCYTOSIS • DIGEST IN PHAGOLYSOSOME • FRAGMENTS COMBINE WITH PREFORMED MHC CLASS II • DISPLAYED ON PLASMA MEMBRANE • RECOGNIZED BY CD4 + CELLS ...
The Virus! - Omaha Science Media Project
... even milder for adults. In some cases, however, the virus escapes the intesKnal tract to cause serious disease. In children, coxsackie may go on to produce viral meningiKs and it has been proposed, on the basis of epidemiological evidence, that coxsackie and other enteroviruses (such as ECHO) may ...
... even milder for adults. In some cases, however, the virus escapes the intesKnal tract to cause serious disease. In children, coxsackie may go on to produce viral meningiKs and it has been proposed, on the basis of epidemiological evidence, that coxsackie and other enteroviruses (such as ECHO) may ...
Immunoisolation
... Hematopoietic stem cells give rise to all the types of blood cells: red blood cells, B lymphocytes, T lymphocytes, natural killer cells, neutrophils, basophils, eosinophils, monocytes, and macrophages. Mesenchymal stem cells have been reported to be present in many tissues. Those from bone marrow (b ...
... Hematopoietic stem cells give rise to all the types of blood cells: red blood cells, B lymphocytes, T lymphocytes, natural killer cells, neutrophils, basophils, eosinophils, monocytes, and macrophages. Mesenchymal stem cells have been reported to be present in many tissues. Those from bone marrow (b ...
Overview of the Immune System in Transplantation
... As mentioned, T-cells are the first to respond to the presence of anything “non-self.” Cellular immunity is particularly active against viruses, for example. The T-cells transfer their knowledge to B-cells for specific antibody production. This humoral immunity plays a major role against bacterial p ...
... As mentioned, T-cells are the first to respond to the presence of anything “non-self.” Cellular immunity is particularly active against viruses, for example. The T-cells transfer their knowledge to B-cells for specific antibody production. This humoral immunity plays a major role against bacterial p ...
Anaphylaxis and the immune system - practice
... How it looks in the Green Book 1. Send for additional health professional assistance 2. Send a responsible adult to dial 999 and state that there is a case of suspected anaphylaxis 3. Stay with the patient at all times 4. Lie the patient down, ideally with the legs raised (unless the patient has b ...
... How it looks in the Green Book 1. Send for additional health professional assistance 2. Send a responsible adult to dial 999 and state that there is a case of suspected anaphylaxis 3. Stay with the patient at all times 4. Lie the patient down, ideally with the legs raised (unless the patient has b ...
SKIN
... The cells extend slightly around the tonofibrils on both sides of each desmosome (and the extensions elongate if the cells shrink slightly during histologic processing), leading to the appearance of many short “spines” or prickles at the cell surfaces . The epidermis of thick skin subject to continu ...
... The cells extend slightly around the tonofibrils on both sides of each desmosome (and the extensions elongate if the cells shrink slightly during histologic processing), leading to the appearance of many short “spines” or prickles at the cell surfaces . The epidermis of thick skin subject to continu ...
Histocompatibility
... There may be over 60 distinct genes assigned to the H-2 complex. It is principally, but not exclusively, the H-2 gene products that regulate the processes of transplantation, immune responsiveness and aspects of complement synthesis. These products may serve more than one function. Each gene of the ...
... There may be over 60 distinct genes assigned to the H-2 complex. It is principally, but not exclusively, the H-2 gene products that regulate the processes of transplantation, immune responsiveness and aspects of complement synthesis. These products may serve more than one function. Each gene of the ...
Central Nervous System Control of The Immune System
... maturation and selection prior to being released into the circulation of the immune system. This process allows T cells to develop self-tolerance (distinguishing self from non-self). While developing in the thymus gland, any T cell that reacts to the thymus's major histocompatibility complex (MHC) i ...
... maturation and selection prior to being released into the circulation of the immune system. This process allows T cells to develop self-tolerance (distinguishing self from non-self). While developing in the thymus gland, any T cell that reacts to the thymus's major histocompatibility complex (MHC) i ...
Dendritic cell
... Bone marrow-derived cells present in the skin and mucosal epithelium abundant cytoplasmic granules filled with cytokines, histamine, and other mediators not found in the circulation round nuclei, and the cytoplasm contains membranebound granules granules contain acidic proteoglycans that bind basic ...
... Bone marrow-derived cells present in the skin and mucosal epithelium abundant cytoplasmic granules filled with cytokines, histamine, and other mediators not found in the circulation round nuclei, and the cytoplasm contains membranebound granules granules contain acidic proteoglycans that bind basic ...
Lymphatic & Immune System - Sonoma Valley High School
... Lack of self tolerance results in autoimmune diseases ...
... Lack of self tolerance results in autoimmune diseases ...
Autoimmunity and autoimmune disease
... the CD4 helper T cells are tolerant at lower concentrations of autoantigens or because they only recognize cryptic epitopes. When a cross-reacting microbial antigen bears a new carrier epitope to which T cells are not tolerant, these inactive B cells can be switched on. The activated B cells now pre ...
... the CD4 helper T cells are tolerant at lower concentrations of autoantigens or because they only recognize cryptic epitopes. When a cross-reacting microbial antigen bears a new carrier epitope to which T cells are not tolerant, these inactive B cells can be switched on. The activated B cells now pre ...
immune system 101
... Your immune system has many different ways of fighting off foreign invaders. When confronted with a virus, your body responds by activating specific processes of the immune system. First your body recognizes a foreign antigen and delivers it to the lymph system, where it is ingested by a macrophage. ...
... Your immune system has many different ways of fighting off foreign invaders. When confronted with a virus, your body responds by activating specific processes of the immune system. First your body recognizes a foreign antigen and delivers it to the lymph system, where it is ingested by a macrophage. ...
Cytokines
... Another feature common to most of the hematopoietin (class I cytokine) is multiple subunits, often including one subunit that binds specific cytokine molecules and another that mediates signal transduction. ...
... Another feature common to most of the hematopoietin (class I cytokine) is multiple subunits, often including one subunit that binds specific cytokine molecules and another that mediates signal transduction. ...
Document
... BcR and initiation of Signalling: The BcR of naïve B cells is IgM. (Of course, this can/will change if isotype switching occurs later). IgM is associated with two other chains called Ig-alpha and Ig-beta (analogous to CD3 complex in T cells). These two chains contain the ITAM motifs which, when phos ...
... BcR and initiation of Signalling: The BcR of naïve B cells is IgM. (Of course, this can/will change if isotype switching occurs later). IgM is associated with two other chains called Ig-alpha and Ig-beta (analogous to CD3 complex in T cells). These two chains contain the ITAM motifs which, when phos ...
Tumor Immunology - UCSF Immunology Program
... approaches to break tolerance against self-antigens, and characterizing effector and memory T cells following tumor immunotherapy. Dendritic cell function Dendritic cells (DC) are known to be comprised of multiple subsets (e.g. myeloid DC, plasmacytoid DC), each of which may have distinct functions. ...
... approaches to break tolerance against self-antigens, and characterizing effector and memory T cells following tumor immunotherapy. Dendritic cell function Dendritic cells (DC) are known to be comprised of multiple subsets (e.g. myeloid DC, plasmacytoid DC), each of which may have distinct functions. ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.