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... a technique first described by DeLong to generate reaggregating cell cultures from fetal mouse isocortex and hippocampus (1). Dr Pulliam used BrnAggs to study human immunodeficiency virus and herpes simplex virus encephalitis (2Y5). Ours is the first study of prion disease in BrnAggs. Brain aggregates ...
... a technique first described by DeLong to generate reaggregating cell cultures from fetal mouse isocortex and hippocampus (1). Dr Pulliam used BrnAggs to study human immunodeficiency virus and herpes simplex virus encephalitis (2Y5). Ours is the first study of prion disease in BrnAggs. Brain aggregates ...
Two-Photon Targeted Patching and Electroporation In Vivo
... most numerous cell types being more readily sampled than the smallest or least abundant cells. This is, of course, dependent on the overall architecture of the brain area of interest, but in many regions that contain anatomically, genetically, and functionally diverse populations of neurons, such as ...
... most numerous cell types being more readily sampled than the smallest or least abundant cells. This is, of course, dependent on the overall architecture of the brain area of interest, but in many regions that contain anatomically, genetically, and functionally diverse populations of neurons, such as ...
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... They were considered to be the passive bystanders of neural transmission. However, recent studies have shown this to be untrue. For example, astrocytes are crucial in clearance of neurotransmitter from within the synaptic cleft, which provides distinction between arrival of action potentials and pre ...
... They were considered to be the passive bystanders of neural transmission. However, recent studies have shown this to be untrue. For example, astrocytes are crucial in clearance of neurotransmitter from within the synaptic cleft, which provides distinction between arrival of action potentials and pre ...
Neurotransmitters:
... dendrite of another. This signal has to cross a small gap called a synapse. Chemicals called neurotransmitters, produced in the nerve cells themselves, are the chemical messengers that carry these signals from one cell to another. We’ll model neurotransmitters with Smarties!! There are many differen ...
... dendrite of another. This signal has to cross a small gap called a synapse. Chemicals called neurotransmitters, produced in the nerve cells themselves, are the chemical messengers that carry these signals from one cell to another. We’ll model neurotransmitters with Smarties!! There are many differen ...
Two different lateral amygdala cell populations contribute to the
... levels during the first two 4-trial blocks of conditioning, and then tended to diminish during later conditioning trials (Fig. 5b). To determine how individual cells contributed to this pattern, a ‘persistence’ value was quantified for each cell by dividing the increase in CS responses (over habitua ...
... levels during the first two 4-trial blocks of conditioning, and then tended to diminish during later conditioning trials (Fig. 5b). To determine how individual cells contributed to this pattern, a ‘persistence’ value was quantified for each cell by dividing the increase in CS responses (over habitua ...
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... The mammalian cortex is a multilaminar structure consisting of specialized layer-specific neurons that form complex circuits throughout the brain and spinal cord. These neurons are generated in a defined sequence dictated by their birthdate such that early-born neurons settle in deep cortical layers ...
... The mammalian cortex is a multilaminar structure consisting of specialized layer-specific neurons that form complex circuits throughout the brain and spinal cord. These neurons are generated in a defined sequence dictated by their birthdate such that early-born neurons settle in deep cortical layers ...
Opposite rheological properties of neuronal microcompartments
... demonstrated by the increase of the Young’s modulus with stress (Fig. 3E), while it remained solid-like with no significant changes in the b parameter (Fig. 3F). In contrast, the neurite compartment fluidized significantly (increase of b exponent) with the applied stresses in the range 20–400 Pa (Fi ...
... demonstrated by the increase of the Young’s modulus with stress (Fig. 3E), while it remained solid-like with no significant changes in the b parameter (Fig. 3F). In contrast, the neurite compartment fluidized significantly (increase of b exponent) with the applied stresses in the range 20–400 Pa (Fi ...
Biological Bases Powerpoint – Neurons
... After an action potential, the minimum length of time during which another action potential cannot begin The “recharging phase” (1-2 milliseconds) The nerve WILL NOT respond to a second stimulus ...
... After an action potential, the minimum length of time during which another action potential cannot begin The “recharging phase” (1-2 milliseconds) The nerve WILL NOT respond to a second stimulus ...
Citron-Kinase, a Protein Essential to Cytokinesis in Neuronal
... forebrain of fh/fh mutants is approximately one-half the size of wt rats, a difference that is present as early as P0 (Roberts et al., 2000). As shown in Figure 1 B–D, the neocortex of fh/fh mutants contains both binucleate nonpyramidal (Fig. 1 B) and pyramidal neurons (Fig. 1C), and in electron mic ...
... forebrain of fh/fh mutants is approximately one-half the size of wt rats, a difference that is present as early as P0 (Roberts et al., 2000). As shown in Figure 1 B–D, the neocortex of fh/fh mutants contains both binucleate nonpyramidal (Fig. 1 B) and pyramidal neurons (Fig. 1C), and in electron mic ...
INFORMATION PROCESSING WITH POPULATION CODES
... concerns how information is encoded by the neural architecture of the brain. What are the units of computation and how is information represented at the neural level? An important part of the answers to these questions is that individual elements of information are encoded not by single cells, but r ...
... concerns how information is encoded by the neural architecture of the brain. What are the units of computation and how is information represented at the neural level? An important part of the answers to these questions is that individual elements of information are encoded not by single cells, but r ...
Bayer Exp Br Res 1983
... (Bayer and Altman 1974). This method provides an accurate estimate of the proportion of neurons originating on each day of embryonic life and on blocks of two to four days of early postnatal life. The rationale for initiating this research was to see whether or not the chronology of neurogenesis wit ...
... (Bayer and Altman 1974). This method provides an accurate estimate of the proportion of neurons originating on each day of embryonic life and on blocks of two to four days of early postnatal life. The rationale for initiating this research was to see whether or not the chronology of neurogenesis wit ...
Hippocampus, hippocampal sclerosis and epilepsy
... Molecular studies in recent years have added additional information on the pathogenesis of TLE and HS. Processes such as synaptic plasticity and glial reaction play an extremely important role. The most important pathogenic factor in synaptic plasticity is the reorganization of the structure and fun ...
... Molecular studies in recent years have added additional information on the pathogenesis of TLE and HS. Processes such as synaptic plasticity and glial reaction play an extremely important role. The most important pathogenic factor in synaptic plasticity is the reorganization of the structure and fun ...
Proceedings - Neuroscience Meetings
... Summary. Single episode of generalized tonic-clonic seizures induced by pentylenetetrazole led to slowly developing memory impairments in rats, accompanied by elimination of excessive newly generated young cells which were born in the hippocampus soon after the seizures and transient activation of m ...
... Summary. Single episode of generalized tonic-clonic seizures induced by pentylenetetrazole led to slowly developing memory impairments in rats, accompanied by elimination of excessive newly generated young cells which were born in the hippocampus soon after the seizures and transient activation of m ...
Glioblastoma - The Brain Tumour Charity
... oxygen and nutrients and remove dead cells, supporting and protecting the neurons. Glial cells are much smaller than neurons and we have many more glial cells than neurons. There are different types of glial cell, each of which play a different role in supporting the neurons. The main types are astr ...
... oxygen and nutrients and remove dead cells, supporting and protecting the neurons. Glial cells are much smaller than neurons and we have many more glial cells than neurons. There are different types of glial cell, each of which play a different role in supporting the neurons. The main types are astr ...
Consciousness_12
... every part of "the writing" contains information about the whole. A hologram (the material manifestation of a holograph) is a photographic emulsion in which information about a scene is recorded in a very special way. When the hologram is illuminated, you see a realistic, 3-dimensional representatio ...
... every part of "the writing" contains information about the whole. A hologram (the material manifestation of a holograph) is a photographic emulsion in which information about a scene is recorded in a very special way. When the hologram is illuminated, you see a realistic, 3-dimensional representatio ...
NIH Public Access
... Toward the end of the 1990s, technological and methodological advances allowed for more precise measurement of cortical thickness (Fischl and Dale 2000; Kabani et al. 2001), which is considered to reflect the packing density of neurons, as well as other components of the neuropil. Similar to volume, ...
... Toward the end of the 1990s, technological and methodological advances allowed for more precise measurement of cortical thickness (Fischl and Dale 2000; Kabani et al. 2001), which is considered to reflect the packing density of neurons, as well as other components of the neuropil. Similar to volume, ...
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... Guilfoyle, 2006). In order to carry out their information processing functions, neurons require large amounts of energy, and their lifeline for this energy is the circulatory system upon which they rely for a continuous supply of nutrients and for removal of metabolic waste products and heat. Thus, ...
... Guilfoyle, 2006). In order to carry out their information processing functions, neurons require large amounts of energy, and their lifeline for this energy is the circulatory system upon which they rely for a continuous supply of nutrients and for removal of metabolic waste products and heat. Thus, ...
Dissecting differential gene expression within the circadian neuronal
... circumvent mRNA oscillations as a defining property, we developed a method to identify mRNAs enriched within different subsets of well-defined types of brain neuron. Comparing the gene expression profiles from different circadian cell groups, we identified many new genes specifically expressed in a ...
... circumvent mRNA oscillations as a defining property, we developed a method to identify mRNAs enriched within different subsets of well-defined types of brain neuron. Comparing the gene expression profiles from different circadian cell groups, we identified many new genes specifically expressed in a ...
Glioblastoma - The Brain Tumour Charity
... The chemoradiation is used to slow the growth of any tumour cells that cannot be removed by surgery. Chemoradiation comprises radiotherapy over a period of weeks and rounds of the chemotherapy drug temozolomide (TMZ). Temozolomide works by stopping tumour cells from making new DNA (the material that ...
... The chemoradiation is used to slow the growth of any tumour cells that cannot be removed by surgery. Chemoradiation comprises radiotherapy over a period of weeks and rounds of the chemotherapy drug temozolomide (TMZ). Temozolomide works by stopping tumour cells from making new DNA (the material that ...
Subventricular zone
The subventricular zone (SVZ) is a paired brain structure situated throughout the lateral walls of the lateral ventricles. It is composed of four distinct layers of variable thickness and cell density, as well as cellular composition. Along with the dentate gyrus of the hippocampus, the SVZ is one of two places where neurogenesis has been found to occur in the adult mammalian brain.