Faculty Details proforma for DU Web-site Title First Name
... Masanao Murakami, Rajeev Kaul, and Erle S Robertson. 2008. MTA1 expression linked to ovarian cancer. Cancer Biology and Therapy. 2008 Sep (9): 1468-1470 Masanao Murakami, Rajeev Kaul, Pankaj Kumar and Erle S Robertson. 2009. Nucleoside Diphosphate Kinase/Nm23 and Epstein Barr Virus. Molecular and Ce ...
... Masanao Murakami, Rajeev Kaul, and Erle S Robertson. 2008. MTA1 expression linked to ovarian cancer. Cancer Biology and Therapy. 2008 Sep (9): 1468-1470 Masanao Murakami, Rajeev Kaul, Pankaj Kumar and Erle S Robertson. 2009. Nucleoside Diphosphate Kinase/Nm23 and Epstein Barr Virus. Molecular and Ce ...
THE ROLE OF THE ret PROTO-ONCOGENE IN HUMAN DISEASE
... MEN 2 SYNDROME DEVELOPMENT MECHANISM BY ret MUTATIONS To investigate whether MEN 2A and MEN 2B mutations represent gain of function mutations of ret, we introduced the mutations into ret cDNA and transfected mutant ret cDNAs into NIH 3T3 cells. As a result, we found that all mutations which were fou ...
... MEN 2 SYNDROME DEVELOPMENT MECHANISM BY ret MUTATIONS To investigate whether MEN 2A and MEN 2B mutations represent gain of function mutations of ret, we introduced the mutations into ret cDNA and transfected mutant ret cDNAs into NIH 3T3 cells. As a result, we found that all mutations which were fou ...
Genetics of Epilepsy - Center for Neurosciences
... Other exome screens in patients and their immediate families with neurological disorders have since demonstrated high rates of success However, exome screening still has a few disadvantages These can be improved by (more expensive) Whole Genome Sequencing (WGS) ...
... Other exome screens in patients and their immediate families with neurological disorders have since demonstrated high rates of success However, exome screening still has a few disadvantages These can be improved by (more expensive) Whole Genome Sequencing (WGS) ...
Network properties of human disease genes with pleiotropic effects
... centrality [14]. There are different measures that capture the centrality of a node in a network. We constructed a human protein interaction network using a modified version of CRG interactome [15] and investigated for differences in four different centrality measures namely degree, closeness, betwe ...
... centrality [14]. There are different measures that capture the centrality of a node in a network. We constructed a human protein interaction network using a modified version of CRG interactome [15] and investigated for differences in four different centrality measures namely degree, closeness, betwe ...
one in three hundred sixty thousand
... patients were sensitive to a type of genetic damage called crosslinking, which occurs when the bases that form the DNA molecule stick together during replication. That leads to constant breaking of DNA strands, something most people fix well, but not Fanconi patients. Normal Fanconi genes help find ...
... patients were sensitive to a type of genetic damage called crosslinking, which occurs when the bases that form the DNA molecule stick together during replication. That leads to constant breaking of DNA strands, something most people fix well, but not Fanconi patients. Normal Fanconi genes help find ...
Analysis of Drosophila Species Genome Size and Satellite DNA
... exchange between sister chromatids or replication errors (Britten and Kohne 1968; Southern 1975; Smith 1976; Stephan and Cho 1994; Petrov 2001). Understanding the levels and distributions of heterochromatic repetitive elements across a range of related species will aid in discriminating among the po ...
... exchange between sister chromatids or replication errors (Britten and Kohne 1968; Southern 1975; Smith 1976; Stephan and Cho 1994; Petrov 2001). Understanding the levels and distributions of heterochromatic repetitive elements across a range of related species will aid in discriminating among the po ...
Physical map of the aromatic amine and m-toluate
... present in Pseudomonasputida UCC22, a derivativeof P.putida mt-2. The plasmid is 79 1kbp in size and can be divided into a restriction-site-deficient region of 51 f 1 kbp and a restriction-site-profuse region of 28 kbp which begins and ends with directly repeating sequences of at least 2 kbp in leng ...
... present in Pseudomonasputida UCC22, a derivativeof P.putida mt-2. The plasmid is 79 1kbp in size and can be divided into a restriction-site-deficient region of 51 f 1 kbp and a restriction-site-profuse region of 28 kbp which begins and ends with directly repeating sequences of at least 2 kbp in leng ...
Gekko 4_1 July 29
... gecko mutations discussed here. The next logical step would be to sequence likely candidate genes such as genes that code for tyrosinase, P protein, and tyrosinase-related-protein 1. The ability to find the affected locus and characterize the mutations at a molecular level would provide insight into ...
... gecko mutations discussed here. The next logical step would be to sequence likely candidate genes such as genes that code for tyrosinase, P protein, and tyrosinase-related-protein 1. The ability to find the affected locus and characterize the mutations at a molecular level would provide insight into ...
Genetics - Michael
... crops and domesticated animals. In many early cultures, including those that were the precursors of some of today’s countries, the priests and royal families kept detailed records of lineages and bloodlines in order to establish a hierarchy of power. In the process, they also discovered that some tr ...
... crops and domesticated animals. In many early cultures, including those that were the precursors of some of today’s countries, the priests and royal families kept detailed records of lineages and bloodlines in order to establish a hierarchy of power. In the process, they also discovered that some tr ...
Genome Rearrangements Caused by Depletion of Essential DNA
... DPB11, POL2, POL30, RFC2, and RFC5) caused increased illegitimate mating. DNA2, which functions in Okazaki fragment processing (Budd et al. 2000; Lee et al. 2000) and in DNA repair (Zhu et al. 2008) resulted in increased illegitimate mating, as did repression of the DNA repair genes NSE1 (Santa Mari ...
... DPB11, POL2, POL30, RFC2, and RFC5) caused increased illegitimate mating. DNA2, which functions in Okazaki fragment processing (Budd et al. 2000; Lee et al. 2000) and in DNA repair (Zhu et al. 2008) resulted in increased illegitimate mating, as did repression of the DNA repair genes NSE1 (Santa Mari ...
Genetic loads under fitness
... clone is mutation free the ratchet must click approximately 34 times (i.e. c*34). New asexual clones will most frequently arise carrying as many mutations as the average sexual individual. However, such clones will generate an asexual population with a heavy genetic load and therefore do not repres ...
... clone is mutation free the ratchet must click approximately 34 times (i.e. c*34). New asexual clones will most frequently arise carrying as many mutations as the average sexual individual. However, such clones will generate an asexual population with a heavy genetic load and therefore do not repres ...
Integrated genome sequence and linkage map of physic nut
... length (>100 bp) and the N50 in this study are 13 861 bp and 0.746 Mbp, respectively, which are approximately 1.8 and 46.8 times longer, respectively, than the reported physic nut genome (Hirakawa et al., 2012). As the result of short contigs and scaffolds, too many predicted genes in their study we ...
... length (>100 bp) and the N50 in this study are 13 861 bp and 0.746 Mbp, respectively, which are approximately 1.8 and 46.8 times longer, respectively, than the reported physic nut genome (Hirakawa et al., 2012). As the result of short contigs and scaffolds, too many predicted genes in their study we ...
Gene Section PAX8 (paired box 8) Atlas of Genetics and Cytogenetics
... The mutant proteins have markedly reduced DNA binding with subsequent loss of transcriptional activation function. The mutations are thought to disrupt the pronounced gain of alpha helical PAX8 content that follows the interaction of PAX8 with DNA: they impair the unstructured to structured transiti ...
... The mutant proteins have markedly reduced DNA binding with subsequent loss of transcriptional activation function. The mutations are thought to disrupt the pronounced gain of alpha helical PAX8 content that follows the interaction of PAX8 with DNA: they impair the unstructured to structured transiti ...
(F193L) in the KCNQ1 gene associated with long
... Priori et al. [10] reported that LQTS may appear with a very low penetrance in some families, and the family members considered to be normal may be silent gene carriers and are unexpectedly at risk of developing torsades de pointes when they are exposed to repolarization-prolonging drugs. Recently, ...
... Priori et al. [10] reported that LQTS may appear with a very low penetrance in some families, and the family members considered to be normal may be silent gene carriers and are unexpectedly at risk of developing torsades de pointes when they are exposed to repolarization-prolonging drugs. Recently, ...
Siberian Husky - Purina Pro Club
... Inherited cataracts in people usually occur in association with metabolic diseases or as part of more complex genetic syndromes.1 There are about 39 genetic loci that have been associated with cataracts in humans, and mutations in specific genes have been identified for approximately 26 of these. ...
... Inherited cataracts in people usually occur in association with metabolic diseases or as part of more complex genetic syndromes.1 There are about 39 genetic loci that have been associated with cataracts in humans, and mutations in specific genes have been identified for approximately 26 of these. ...
here - Genetics
... Some of these alleles may confer on the cell resistance to low levels of streptomycin. some may confer resistance to high levels of streptomycin, and others may make the cell conditionally or absolutely dependent on streptomycin. None of these facts is relevant to the designation of an allele, howev ...
... Some of these alleles may confer on the cell resistance to low levels of streptomycin. some may confer resistance to high levels of streptomycin, and others may make the cell conditionally or absolutely dependent on streptomycin. None of these facts is relevant to the designation of an allele, howev ...
The use of the twin model to investigate the genetics and
... twins are often discordant for diseases. Progress made in high throughput genotyping, transcriptomics, methylation studies and RNA sequencing are now showing that some of the unexplained ...
... twins are often discordant for diseases. Progress made in high throughput genotyping, transcriptomics, methylation studies and RNA sequencing are now showing that some of the unexplained ...
Structural Variants in the Human Genome
... genomes and they are a major cause of phenotypic variation • They are common in certain diseases, particularly cancers and behavioral diseases • They are now also showing up in rare diseases and common behavioral diseases such as autism, schizophrenia and many neurological disorders Courtesy of Mike ...
... genomes and they are a major cause of phenotypic variation • They are common in certain diseases, particularly cancers and behavioral diseases • They are now also showing up in rare diseases and common behavioral diseases such as autism, schizophrenia and many neurological disorders Courtesy of Mike ...
Estonian HumanGenesResearchAct.
... a Gene Bank, to organise the genetic research necessary therefor, to ensure the voluntary nature of gene donation and the confidentiality of the identity of gene donors, and to protect persons from misuse of genetic data and from discrimination based on interpretation of the structure of their DNA a ...
... a Gene Bank, to organise the genetic research necessary therefor, to ensure the voluntary nature of gene donation and the confidentiality of the identity of gene donors, and to protect persons from misuse of genetic data and from discrimination based on interpretation of the structure of their DNA a ...
Slides
... Mapping Structural Variation in Humans >1 kb segments - Structural Variations are Common 40% of the genome -Structural Variations are involved in phenotype variation and disease - Until recently most methods for detection were low resolution (>50 kb) ...
... Mapping Structural Variation in Humans >1 kb segments - Structural Variations are Common 40% of the genome -Structural Variations are involved in phenotype variation and disease - Until recently most methods for detection were low resolution (>50 kb) ...
Capstone project 2015 in pdf format
... 3: Genetics of fan morphogenesis by genetic screen with KC62 or derivatives 4: Verification of a global transcription factor to up and down regulation of target gene via differential DNA binding 5: Identification of interacting components in transcriptional machinery for body shape control 6: Geneti ...
... 3: Genetics of fan morphogenesis by genetic screen with KC62 or derivatives 4: Verification of a global transcription factor to up and down regulation of target gene via differential DNA binding 5: Identification of interacting components in transcriptional machinery for body shape control 6: Geneti ...
SEARCH_16S: A new algorithm for identifying 16S
... for a gene of length 1,500bp which is present in GG97, we expect to find 500bp at the start of the gene where the density rises from 120 to 1,000, a flat peak of 500bp in the middle of the gene where the density is maximum, then 500bp at the end of the gene where the density falls from 1,000 back to ...
... for a gene of length 1,500bp which is present in GG97, we expect to find 500bp at the start of the gene where the density rises from 120 to 1,000, a flat peak of 500bp in the middle of the gene where the density is maximum, then 500bp at the end of the gene where the density falls from 1,000 back to ...
Selection against Accumulating Mutations in Niche
... Our current understanding of sympatric speciation is that it occurs primarily through disruptive selection on ecological genes driven by competition, followed by reproductive isolation through reinforcement-like selection against inferior intermediates/heterozygotes. Our evolutionary model of select ...
... Our current understanding of sympatric speciation is that it occurs primarily through disruptive selection on ecological genes driven by competition, followed by reproductive isolation through reinforcement-like selection against inferior intermediates/heterozygotes. Our evolutionary model of select ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.