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Albuterol metered dose inhaler performance under hyperbaric
Albuterol metered dose inhaler performance under hyperbaric

... were fitted by linear regression (GraphPad, San Diego, CA). The mean fractional weight loss of each group of MDIs at 66 compared to 0 fsw was calculated from this regression line. Differences among these means were tested for statistical significance using one way ANOVA followed by Bonferroni’s multip ...
Combined Dieting and Stress Evoke Exaggerated Responses to
Combined Dieting and Stress Evoke Exaggerated Responses to

... eating supports this synergistic effect because stress evokes binge eating only in rats with a history of cyclic caloric restriction (Geary, 2003; Hagan et al., 2002, 2003). Little is known about the neurochemical changes that mediate binge eating. This is the first study aimed at elucidating the ph ...
Epinephrine
Epinephrine

FORMULATION AND EVALUATION OF FAST DISINTIGRATING MELOXICAM TABLETS AND ITS  COMPARISON WITH MARKETED PRODUCT 
FORMULATION AND EVALUATION OF FAST DISINTIGRATING MELOXICAM TABLETS AND ITS  COMPARISON WITH MARKETED PRODUCT 

... dysmenorrhea,  fever  and  as  an  analgesic,  especially  where  there  is  an  inflammatory  component8.  Meloxicam  inhibits  cyclooxygenase  (COX) synthesis.   This  enzyme  is  responsible  for  converting  arachidonic  acid  into  prostaglandin  H2.  This  is  the  first  step  in  the  synthe ...
ASCO 2011 NKTR-102 PopPK Poster
ASCO 2011 NKTR-102 PopPK Poster

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Induction

COMPARITIVE STUDIES OF GLUTATHIONE-S-TRANSFERASE KINETICS IN CONTROL,
COMPARITIVE STUDIES OF GLUTATHIONE-S-TRANSFERASE KINETICS IN CONTROL,

... Cisplatin and etoposide are anticancer drug's used for treatment of various human malignancies. Cisplatin is used for treating solid tumors. The beneficial use of drug is often been mitigated due to its long term toxicities, hepatotoxicity and nephrotoxicity. The drug acts on proximal convoluted tub ...
SYSTEMIC ABSORPTION OF TOPICALLY APPLIED SALICYLIC ACID
SYSTEMIC ABSORPTION OF TOPICALLY APPLIED SALICYLIC ACID

... hours at higher levels (greater than ten grams per ...
Inhibition of N-Nitrosodimethylamine Metabolism
Inhibition of N-Nitrosodimethylamine Metabolism

... magnitude. Johannessen et al. (11 ) found that antipyrine clear ance was not significantly affected by exposing animals to ether for 5-10 min before drug administration, but that continuous ether anesthesia reduced the clearance by roughly 4-fold. In addition continuous ether treatment resulted in a ...
Options of drugs for intermittent presumptive treatment for malaria in
Options of drugs for intermittent presumptive treatment for malaria in

... mediated via prophylaxis, then only long acting drugs can be considered. High levels of SP resistance are recorded in Eastern and Southern Africa. SP resistance is generally lower in West Africa, but this situation will change soon as SP becomes the first line treatment in place of chloroquine which ...
Dabigatran
Dabigatran

Fair Balance (FB)
Fair Balance (FB)

... • Instructions which are covered by standards of practice for all drugs – e.g. instruct patients to keep out of reach of children – e.g. only physicians who are knowledgeable with the product or class should prescribe ...
A study with cumulative doses of formoterol and salbutamol in
A study with cumulative doses of formoterol and salbutamol in

FORMULATION OF RAPID MOUTH DISSOLVING TABLETS OF CETIRIZINE di HCL USING  SUBLIMATION METHOD  Research Article   
FORMULATION OF RAPID MOUTH DISSOLVING TABLETS OF CETIRIZINE di HCL USING  SUBLIMATION METHOD  Research Article   

... individually  before  and  after  sublimation  and  from  the  average  weight,  standard  deviation  was  determined.  The  crushing  strength  (Kg/cm 2)  of  prepared  tablets  was  measured  by  using  Monsanto tablet hardness tester. For In vitro disintegration time  study,  no  method  is  avai ...
View - OhioLINK Electronic Theses and Dissertations Center
View - OhioLINK Electronic Theses and Dissertations Center

... oxidase, uses one electron transfers between Cu+ to Cu2+ oxidation state, to catalyze the reduction of molecular oxygen (O2) to water (H2O) and therefore creates an electrical gradient used by the mitochondria to create ATP3. Four copper containing enzymes known as the multi-copper oxidases (MCO) or ...
Characterization of diffusion and duration of action of a
Characterization of diffusion and duration of action of a

... and duration of muscle paralysis after toxin injection. 2.2.1. Muscle force generation (MFG) Animals were anesthetized with isoflurane (1.25%, mixed with oxygen), and the test articles, RT002 or Botox (5 mL in 0.9% saline) were unilaterally injected into the right gastrocnemius muscle based on body w ...
- Journal of Advanced Drug Delivery
- Journal of Advanced Drug Delivery

... solution were applied on HPTLC plate (12 µl each, i.e. 1200 ng per spot). The chromatograms were run as described in Section 2.2. 2.6.2. Hydrogen peroxide-induced degradation The 10 mg of palonosetron hydrochloride was separately dissolved in 10 ml of ethanolic solution of hydrogen peroxide (3.0%, v ...
Citalopram-Induced Long QT Syndrome and the Mammalian Dive
Citalopram-Induced Long QT Syndrome and the Mammalian Dive

... not quantified. While a high level of caffeine might have contributed to the fatal outcome, it seems unlikely since caffeine is routinely ‘positive’ in the blood of those who consume beverages containing caffeine. In view of the ‘‘slightly enlarged heart’’ and level of citalopram, and in the absence ...
Nessun titolo diapositiva
Nessun titolo diapositiva

... • Symptoms include severe pain and dyspnea ...
DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION SPECTROPHOTOMETRIC
DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION SPECTROPHOTOMETRIC

... Calibration curves were constructed by plotting average absorbance versus concentrations for both drugs. Straight line equations were obtained from these calibration curves. Accuracy ...
Mastic Gum Kills Helicobacter pylori
Mastic Gum Kills Helicobacter pylori

... was 0.06 mg of the crude mastic per milliliter. At lower concentrations, bacterial growth was still significantly inhibited, with a clear postantibiotic effect even at the lowest concentration used, 0.0075 mg per milliliter. Mastic induced clear ultrastructural changes in the organism, as demonstrat ...


... between these compounds, however, there are numerous benefits for isolating and identifying active constituents from these bioactive plants. These benefits include characterising toxicity profiles, simpler determination of modes of action, and new activities of known compound which adds to the wealt ...
CHROMATOGRAPHIC AND MASS SPECTRAL STUDIES ON MASS
CHROMATOGRAPHIC AND MASS SPECTRAL STUDIES ON MASS

The Role of Anabolic Hormones for Wound Healing in Catabolic
The Role of Anabolic Hormones for Wound Healing in Catabolic

- Wiley Online Library
- Wiley Online Library

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Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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