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Slide 1
Slide 1

... 1700 – Laënnec’s stethoscope ...
The Heart
The Heart

...  Blood in the heart chambers does not nourish the myocardium  The heart has its own nourishing circulatory system consisting of  Coronary arteries—branch from the aorta to supply the heart muscle with oxygenated blood  Cardiac veins—drain the myocardium of blood  Coronary sinus—a large vein on ...
096 Heart rate reserve in ACHD - Diller - Circ 2006
096 Heart rate reserve in ACHD - Diller - Circ 2006

... heart rate achieved. Ventilation, oxygen uptake, and carbon dioxide production were measured continuously using a respiratory mass spectrometer (Amis 2000; Innovision, Odense, Denmark) as described previously (16). Heart rate was assessed by continuous electrocardiography, and arterial blood pressur ...
MITRAL VALVE REGURGITATION
MITRAL VALVE REGURGITATION

... heart have to work harder to get blood out to your body. If the regurgitation gets worse, some blood may start to back up into your lungs. Mitral valve regurgitation can increase risk for other heart rhythm problems, such as atrial fibrillation (a-fib). This is a condition where the heart beats very ...
New Targets to Treat the Structural Remodeling of the
New Targets to Treat the Structural Remodeling of the

... chronic heart failure (HF) (Fig. 1). HF has become a major clinical and public health challenge. Since conventional strategies for the treatment of HF are still largely based on targeting its causes and its neurohumoral consequences, a broader perspective may be useful for the development of novel m ...
Distribution of normal human left ventricular myofiber stress at end
Distribution of normal human left ventricular myofiber stress at end

... end diastole and end systole: a target for in silico design of heart failure treatments. J Appl Physiol 117: 142–152, 2014. First published May 29, 2014; doi:10.1152/japplphysiol.00255.2014.—Ventricular wall stress is believed to be responsible for many physical mechanisms taking place in the human ...
sample pdf - Fast Facts
sample pdf - Fast Facts

... • a trigger – a feature that initiates the arrhythmia: the most common form is an atrial or ventricular ectopic beat. Accessory pathways. The best-described mechanism of re-entry is that due to an accessory pathway – an abnormal connection between the atria and ventricle that bypasses the specializ ...
EHAC Course
EHAC Course

... which leads to chest pain which leads to unstable angina worsening which leads to damaging myocardial infarction which leads to sudden death. Before chest pain there is in most cases a milder form of chest discomfort that is centrally located coming and going that may be present for hours and/or day ...
HCM - cardiology zagazig university
HCM - cardiology zagazig university

... diffuse or focal wall dysfunction similar to RV that may be progressive in nature Left V dysfunction may be best evidenced with exercise ...
Congenital Absence of the Pulmonary Valve
Congenital Absence of the Pulmonary Valve

... Findings in our patient did not correlate with these criteria. He was a 56-year-old man with severe three vessel arteriosclerotic coronary artery disease who presented with pericardial effusion secondary to hemopericardium. If a patient presents with acute myocardial infarction and bloody pericardia ...
Expert consensus document on b-adrenergic receptor blockers of Cardiology
Expert consensus document on b-adrenergic receptor blockers of Cardiology

... refractory period of AV node), reduces the sympathetic drive and myocardial ischaemia, improves baroreflex function and prevents catecholamine-induced hypokalemia.13 Other mechanisms include: inhibition of cardiac apoptosis mediated via the activation of the b-adrenergic pathway,14 inhibition of plat ...
Sodium Channel Mutations and Susceptibility to Heart Failure and
Sodium Channel Mutations and Susceptibility to Heart Failure and

... normal exons generating single peaks on chromatographic profiles, exons harboring mutations had anomalous profiles characterized by 2 peaks. B, To determine if detected variations were benign or pathogenic, genomic DNA sequencing was performed. In 4 of the exons (exons 6, 16, 21, and 27), mutations ...
Birger Axelsson - Umeå universitet
Birger Axelsson - Umeå universitet

... Abstract Background: Myocardial failure and dysfunction is not uncommon during critical illness and following cardiac surgery. For optimal treatment, a better understanding of the effects of inotropic drugs is needed. In this thesis, two non-adrenergic mediated inotropes, milrinone and levosimendan, ...
12 Lead EKG and Acute Myocardial Infarction:
12 Lead EKG and Acute Myocardial Infarction:

... Method of the EKG • Electrode: Conductor of electrical activity applied to the skin •Lead: Gives continuous recording between any two electrodes or between one electrode and combination of the others • made up of positive and negative electrode • the term “lead” is two-fold: –The position of the el ...
Copyright Information of the Article Published Online TITLE
Copyright Information of the Article Published Online TITLE

... approximately 2.5% of non-ST elevation MIs[5]. Moreover, mechanical complications, such as ventricular septal rupture, acute severe mitral regurgitation and contained free wall rupture may lead to CS and must be suspected in patients with CS complicating non-anterior MI[6]. Other less frequent cause ...
Print - Circulation Research
Print - Circulation Research

... 0.5-1.0 minute after the start of the formalin perfusion. This permitted a continuous flow of the fixative through the vascular system and prevented extensive tissue distension. Approximately 500 ml of 10% formalin was perfused through each rat during the 2 hours of fixation. It must be emphasized t ...
SERIES ‘‘PHYSIOLOGY IN RESPIRATORY MEDICINE’’ A.T. Dinh-Xuan
SERIES ‘‘PHYSIOLOGY IN RESPIRATORY MEDICINE’’ A.T. Dinh-Xuan

... based on the isovolumic part of the measured right ventricle pressure curve only and the fit is thus sensitive to errors and requires high quality right ventricular pressure curves. Using catheter-tip manometers and measuring more pressure curves can partially overcome this problem. The choice of th ...
Happy heart syndrome
Happy heart syndrome

... negative emotional triggers have led to the popular term ‘broken heart syndrome’.4 It is well known that emotional distress may result in an overstimulation of the sympathetic nervous system and/or inappropriate parasympathetic withdrawal.5 As a consequence, the resulting cardiovascular effects may ...
Prevalence of left ventricular dysfunction in a UK community sample
Prevalence of left ventricular dysfunction in a UK community sample

... an ejection fraction (EF) cut-off point of 50% or less to define LV systolic dysfunction, with 40% or less defining moderate/severe dysfunction. In subsidiary analyses (presented in the online appendix), LV systolic function was graded as normal (EF 55% or higher), mild (EF 45e54%), moderate (EF 36e44 ...
With right → left shunt
With right → left shunt

... Valve of sinus venosus (L): part of atrial septum Common atrium: rough part of right and left atria and the auricles Embryonic pulmonary vein: large part of the left atrial wall Septum primum: left side of the atrial septum Septum secundum: right side of the atrial septum Foramen secundum: dimple in ...
a mathematical cardiovascular model with pulsatile and non
a mathematical cardiovascular model with pulsatile and non

... heart compartment representing the left ventricle. The model was used to analyze cerebral blood flow velocity and finger blood pressure measurements during orthostatic stress (sit-to-stand). The aim of this study is to construct a global cardiovascular model combining pulsatile and non-pulsatile com ...
no animations - 6 MB PDF - UNC Heart Sounds Project
no animations - 6 MB PDF - UNC Heart Sounds Project

... this recording. The murmur has more variable pitch than the murmur of a VSD. ...
magos tibor
magos tibor

... potential patterns though the numerical values are often quite different. In some recent solutions: • truncated singular-value decomposition (TSVD) methods, or • least-squares QR (LSQR) method, based on Lanczos bidiagonalization and QR factorization was used. • Results show that the inverse solution ...
Giant right ventricular outflow tract thrombus in hereditary
Giant right ventricular outflow tract thrombus in hereditary

... episode of hemoptysis. A second helical CT-pulmonary angiography was performed, showing a consolidation in the right inferior lobe (Fig. 1) and suspicion of a thrombus in the right ventricle (Fig. 2). The lung consolidation was interpreted as a pulmonary infarction due to pulmonary embolism from the ...
Document
Document

... The right ventricle remodeling is concomitant with an increase in the pulmonary resistance (Fig. 1). When the pulmonary arterial pressure progressively increases from a normal value (Fig. 1a) to a value corresponding to a light pulmonary hypertension (Fig. 1b), pulmonary arteries are slightly vasoco ...
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Heart failure



Heart failure (HF), often referred to as congestive heart failure (CHF), occurs when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs. The terms chronic heart failure (CHF) or congestive cardiac failure (CCF) are often used interchangeably with congestive heart failure. Signs and symptoms commonly include shortness of breath, excessive tiredness, and leg swelling. The shortness of breath is usually worse with exercise, while lying down, and may wake the person at night. A limited ability to exercise is also a common feature.Common causes of heart failure include coronary artery disease including a previous myocardial infarction (heart attack), high blood pressure, atrial fibrillation, valvular heart disease, excess alcohol use, infection, and cardiomyopathy of an unknown cause. These cause heart failure by changing either the structure or the functioning of the heart. There are two main types of heart failure: heart failure due to left ventricular dysfunction and heart failure with normal ejection fraction depending on if the ability of the left ventricle to contract is affected, or the heart's ability to relax. The severity of disease is usually graded by the degree of problems with exercise. Heart failure is not the same as myocardial infarction (in which part of the heart muscle dies) or cardiac arrest (in which blood flow stops altogether). Other diseases that may have symptoms similar to heart failure include obesity, kidney failure, liver problems, anemia and thyroid disease.The condition is diagnosed based on the history of the symptoms and a physical examination with confirmation by echocardiography. Blood tests, electrocardiography, and chest radiography may be useful to determine the underlying cause. Treatment depends on the severity and cause of the disease. In people with chronic stable mild heart failure, treatment commonly consists of lifestyle modifications such as stopping smoking, physical exercise, and dietary changes, as well as medications. In those with heart failure due to left ventricular dysfunction, angiotensin converting enzyme inhibitors or angiotensin receptor blockers along with beta blockers are recommended. For those with severe disease, aldosterone antagonists, or hydralazine plus a nitrate may be used. Diuretics are useful for preventing fluid retention. Sometimes, depending on the cause, an implanted device such as a pacemaker or an implantable cardiac defibrillator may be recommended. In some moderate or severe cases cardiac resynchronization therapy (CRT) may be suggested or cardiac contractility modulation may be of benefit. A ventricular assist device or occasionally a heart transplant may be recommended in those with severe disease despite all other measures.Heart failure is a common, costly, and potentially fatal condition. In developed countries, around 2% of adults have heart failure and in those over the age of 65, this increases to 6–10%. In the year after diagnosis the risk of death is about 35% after which it decreases to below 10% each year. This is similar to the risks with a number of types of cancer. In the United Kingdom the disease is the reason for 5% of emergency hospital admissions. Heart failure has been known since ancient times with the Ebers papyrus commenting on it around 1550 BCE.
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