Immune Senescence A Role for Immature Myeloid Cells in
... The reduced efficiency of the mammalian immune system with aging increases host susceptibility to infectious and autoimmune diseases. However, the mechanisms responsible for these pathologic changes are not well understood. In this study, we demonstrate that the bone marrow, blood, and secondary lym ...
... The reduced efficiency of the mammalian immune system with aging increases host susceptibility to infectious and autoimmune diseases. However, the mechanisms responsible for these pathologic changes are not well understood. In this study, we demonstrate that the bone marrow, blood, and secondary lym ...
T Cell Nitric Oxide Regulates BAFF Expression and
... in NOS22/2 Tip-DCs. The differences in the requirement for NO in promoting IgA responses and for NO in inhibiting IgG responses could be due to factors including the type and source of Ag and/or the localization and type of cells producing NO. Given the importance of the spleen in TI-2 Ab responses ...
... in NOS22/2 Tip-DCs. The differences in the requirement for NO in promoting IgA responses and for NO in inhibiting IgG responses could be due to factors including the type and source of Ag and/or the localization and type of cells producing NO. Given the importance of the spleen in TI-2 Ab responses ...
Characterization of mesenchymal stem cells under the stimulation of
... system to exogenous or endogenous products of virus or bacteria. Mesenchymal stem cells (MSCs) can be exposed to this infective environment, which may change the characteristics and therapeutic potency of these MSCs. MSCs have the ability to repair damaged and inflamed tissues and regulate immune re ...
... system to exogenous or endogenous products of virus or bacteria. Mesenchymal stem cells (MSCs) can be exposed to this infective environment, which may change the characteristics and therapeutic potency of these MSCs. MSCs have the ability to repair damaged and inflamed tissues and regulate immune re ...
(Poly(I:C)) Induces Stable Maturation of Polyriboinosinic
... of supernatants of activated monocytes (monocyte-conditioned medium (MCM)). MCM contains an undefined mixture of cytokines and is difficult to standardize. Here we report that stable maturation of DC can be simply induced by the addition of polyriboinosinic polyribocytidylic acid (poly(I:C)), a synt ...
... of supernatants of activated monocytes (monocyte-conditioned medium (MCM)). MCM contains an undefined mixture of cytokines and is difficult to standardize. Here we report that stable maturation of DC can be simply induced by the addition of polyriboinosinic polyribocytidylic acid (poly(I:C)), a synt ...
Thyroid Glossary - YOUR THYROID And YOU
... Apnea - Temporary absence of breathing. Sleep Apnea which occurs while sleeping. Arrhythmia - An irregular pulse or abnormal heartbeat. Artrial Fibrillation - Common heart arrythmia with rapid beating in upper chambers. Asymptomatic -Having no signs or symptoms of disease. Atypical - Not typical ; n ...
... Apnea - Temporary absence of breathing. Sleep Apnea which occurs while sleeping. Arrhythmia - An irregular pulse or abnormal heartbeat. Artrial Fibrillation - Common heart arrythmia with rapid beating in upper chambers. Asymptomatic -Having no signs or symptoms of disease. Atypical - Not typical ; n ...
References
... Maartens, G., Wilkinson, R.J., Tuberculosis. Lancet, 2010. 370: p. 2030–43. Barry 3rd, C.E., New horizons in the treatment of tuberculosis. Biochem Pharmacol, 1997. 54(11): p. 1165-1172. Ramsden, J.J., What is nanotechnology? . Nanotechnology Perceptions, 2005. 1: p. 3-17. Wagner, V., Dullaart, A., ...
... Maartens, G., Wilkinson, R.J., Tuberculosis. Lancet, 2010. 370: p. 2030–43. Barry 3rd, C.E., New horizons in the treatment of tuberculosis. Biochem Pharmacol, 1997. 54(11): p. 1165-1172. Ramsden, J.J., What is nanotechnology? . Nanotechnology Perceptions, 2005. 1: p. 3-17. Wagner, V., Dullaart, A., ...
Gastrointestinal helminths may affect host
... seasonally, at least partly due to seasonal host immune changes. We therefore examined seasonality of immune resource allocation, pathogen abundance and exposure, and interactions between infections and immunity in plains zebra (Equus quagga) in Etosha National Park (ENP), Namibia, a system with str ...
... seasonally, at least partly due to seasonal host immune changes. We therefore examined seasonality of immune resource allocation, pathogen abundance and exposure, and interactions between infections and immunity in plains zebra (Equus quagga) in Etosha National Park (ENP), Namibia, a system with str ...
Maternal endotoxin-induced fetal growth restriction in rats: Fetal
... Background: Porphyromonas gingivalis as a major etiology of periodontal disease can produce virulence factor, lipopolysaccharide/LPS, which is expected to play a role in the intrauterine fetal growth. Trophoblast at the maternal-fetal interface actively participates in response to infection through ...
... Background: Porphyromonas gingivalis as a major etiology of periodontal disease can produce virulence factor, lipopolysaccharide/LPS, which is expected to play a role in the intrauterine fetal growth. Trophoblast at the maternal-fetal interface actively participates in response to infection through ...
Not Signaling Mechanisms of Innate Immune Sensing but Human
... type-1 IFNs that possess potent antiviral activities (11, 12). In contrast, TLRs 1, 2, 4, 5, and 6 sense outer membrane components of bacteria, fungi, and protozoan organisms, and these receptors are expressed on the surface of mammalian cells. Although most TLRs signal as homodimers, TLR2 requires ...
... type-1 IFNs that possess potent antiviral activities (11, 12). In contrast, TLRs 1, 2, 4, 5, and 6 sense outer membrane components of bacteria, fungi, and protozoan organisms, and these receptors are expressed on the surface of mammalian cells. Although most TLRs signal as homodimers, TLR2 requires ...
Induction of IgA Circulating Immune Complexes after
... counter (13). All serum samples were tested in duplicate in both the (greater than 2 test units) on baseline samples (Table I). All 5 IgG CIC and IgA eIC assays. It is the custom in immune complex assays to introduce an external patients had elevated levels of IgA eIe within 300 min after being fed ...
... counter (13). All serum samples were tested in duplicate in both the (greater than 2 test units) on baseline samples (Table I). All 5 IgG CIC and IgA eIC assays. It is the custom in immune complex assays to introduce an external patients had elevated levels of IgA eIe within 300 min after being fed ...
Active Infection and RIG-I Signaling Influenza A Virus Infection Is
... macrophages, dendritic cells, and mast cells. However, the role of mast cells during respiratory infections is an understudied area (7). Mast cells are tissue-sentinel cells of hematopoietic origins found in most vasculature tissue, but they are enriched in tissues that are at environmental interfac ...
... macrophages, dendritic cells, and mast cells. However, the role of mast cells during respiratory infections is an understudied area (7). Mast cells are tissue-sentinel cells of hematopoietic origins found in most vasculature tissue, but they are enriched in tissues that are at environmental interfac ...
LIPOPOLYSACCHARIDE-MEDIATED REGULATION OF IL-17 RECEPTOR LEVELS IN HUMAN MONOCYTES
... regulating the inflammatory responses, and to determining the differentiation of immune cells. A key player in the adaptive response is the CD4+ T helper (Th) cell. These cells are crucial in mediating specific pathogen responses that come later than the innate response, but are more robust and spec ...
... regulating the inflammatory responses, and to determining the differentiation of immune cells. A key player in the adaptive response is the CD4+ T helper (Th) cell. These cells are crucial in mediating specific pathogen responses that come later than the innate response, but are more robust and spec ...
WHO Meeting on Immunological Endpoints for TB Vaccine Trials
... IFN-γ is an example of a cytokine that is stable in culture and that is produced faster than it is consumed by activated cells; therefore, the length of incubation tends to merely increase the cytokine concentrations measured, and may therefore be selected to suit local logistic requirements. Howeve ...
... IFN-γ is an example of a cytokine that is stable in culture and that is produced faster than it is consumed by activated cells; therefore, the length of incubation tends to merely increase the cytokine concentrations measured, and may therefore be selected to suit local logistic requirements. Howeve ...
Juno Therapeutics Adds Adenosine Receptor Antagonist Through
... and healthy volunteers, vipadenant was found to reach serum levels that predict saturation of the A2a receptor and blockade of signaling through this pathway and to be well tolerated in these subjects. In addition to vipadenant, with the transaction Juno has acquired proprietary know-how and intelle ...
... and healthy volunteers, vipadenant was found to reach serum levels that predict saturation of the A2a receptor and blockade of signaling through this pathway and to be well tolerated in these subjects. In addition to vipadenant, with the transaction Juno has acquired proprietary know-how and intelle ...
Drug-induced immune thrombocytopenia
... depend simply on its relative affinity for one or the other of the two macromolecules. An alternative concept proposed to explain drug-dependent antibody binding is that certain drugs induce a structural change in a target GP, leading to the creation of neoepitopes elsewhere in the protein for which ...
... depend simply on its relative affinity for one or the other of the two macromolecules. An alternative concept proposed to explain drug-dependent antibody binding is that certain drugs induce a structural change in a target GP, leading to the creation of neoepitopes elsewhere in the protein for which ...
Complement and its role in innate and adaptive immune
... activation on and around the opsonized surface and terminating in the production of anaphylatoxins and assembly of the MAC [1, 11]. The lectin pathway functions in an analogous, but immunoglobulin-independent, fashion. As opposed to recognizing antigen-antibody immune complexes, the lectin pathway e ...
... activation on and around the opsonized surface and terminating in the production of anaphylatoxins and assembly of the MAC [1, 11]. The lectin pathway functions in an analogous, but immunoglobulin-independent, fashion. As opposed to recognizing antigen-antibody immune complexes, the lectin pathway e ...
Structure and function of human lactalbumin made lethal to tumor
... respectively, together with the enhancement of fluorescence upon binding of ANS, indicating increased exposure of hydrophobic segments [2]. The 1H-NMR spectrum of HAMLET exhibited broad peaks with poor chemical shift dispersion, indicating a protein in conformational exchange on the millisecond times ...
... respectively, together with the enhancement of fluorescence upon binding of ANS, indicating increased exposure of hydrophobic segments [2]. The 1H-NMR spectrum of HAMLET exhibited broad peaks with poor chemical shift dispersion, indicating a protein in conformational exchange on the millisecond times ...
ch_19_lecture_presentation
... • 19-4 Explain the importance of blood typing, and the basis for ABO and Rh incompatibilities. • 19-5 Categorize white blood cell types based on their structures and functions, and discuss the factors that regulate the production of each type. • 19-6 Describe the structure, function, and production ...
... • 19-4 Explain the importance of blood typing, and the basis for ABO and Rh incompatibilities. • 19-5 Categorize white blood cell types based on their structures and functions, and discuss the factors that regulate the production of each type. • 19-6 Describe the structure, function, and production ...
A B - Padis
... through protein-protein interactions and activates promoter activity. Clearly, IRF8 can act either as a repressor or activator, depending on the target DNA sequence, presumably by interacting with different proteins (Tamura et al., 2002). One of the proteins that directly interacts with IRF8 is the ...
... through protein-protein interactions and activates promoter activity. Clearly, IRF8 can act either as a repressor or activator, depending on the target DNA sequence, presumably by interacting with different proteins (Tamura et al., 2002). One of the proteins that directly interacts with IRF8 is the ...
Increase in Peripheral Blood Intermediate Monocytes is Associated
... Antigen-presenting and proinflammatory function of the intermediate monocytes in children with T1DM Because the changes of intermediate phenotypes were associated with the function of intermediate monocytes, we evaluated changes in the antigen-presenting function of this cell subset. The intermediat ...
... Antigen-presenting and proinflammatory function of the intermediate monocytes in children with T1DM Because the changes of intermediate phenotypes were associated with the function of intermediate monocytes, we evaluated changes in the antigen-presenting function of this cell subset. The intermediat ...
Mitochondria-dependent apoptosis and cellular pH regulation
... permeability transition (PT) are unknown, but the ability of compounds such as bongekreic acid and atractyloside, which modulate the adenine nucleotide translocator (ANT), has implicated this transporter involved in exchanging ADP and ATP between mitochondria and cytosol (reviewed in14). When PT occ ...
... permeability transition (PT) are unknown, but the ability of compounds such as bongekreic acid and atractyloside, which modulate the adenine nucleotide translocator (ANT), has implicated this transporter involved in exchanging ADP and ATP between mitochondria and cytosol (reviewed in14). When PT occ ...
PowerPoint® Lecture Presentations prepared by Jason LaPres
... • 19-4 Explain the importance of blood typing, and the basis for ABO and Rh incompatibilities. • 19-5 Categorize white blood cell types based on their structures and functions, and discuss the factors that regulate the production of each type. • 19-6 Describe the structure, function, and production ...
... • 19-4 Explain the importance of blood typing, and the basis for ABO and Rh incompatibilities. • 19-5 Categorize white blood cell types based on their structures and functions, and discuss the factors that regulate the production of each type. • 19-6 Describe the structure, function, and production ...
MHC Chpt. 7
... – Its products play role in discriminating self/non-self – Participant in both humoral and cell-mediated immunity ...
... – Its products play role in discriminating self/non-self – Participant in both humoral and cell-mediated immunity ...
A crucial role for B cells in neuroinvasive scrapie
... receptors for interferon-a/b7 and interferon-g8. For controls, we inoculated inbred mice of strains C57BL/6 and 129Sv, which are the genetic backgrounds of all other mouse strains used. To investigate the role of T cells, we used mice with targeted disruption of the genes encoding CD4 (ref. 9), CD8 ...
... receptors for interferon-a/b7 and interferon-g8. For controls, we inoculated inbred mice of strains C57BL/6 and 129Sv, which are the genetic backgrounds of all other mouse strains used. To investigate the role of T cells, we used mice with targeted disruption of the genes encoding CD4 (ref. 9), CD8 ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.