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Chapter 2: The Immune System
Chapter 2: The Immune System

... swelling and increased blood flow to the area. If there was not this local painful reaction, the infection would not be sealed off and attacked, but could spread throughout the body, with serious results. Similarly, the fever and malaise that are features of the common cold are not caused by the vir ...
Immunity Talk selected slides
Immunity Talk selected slides

... Antigens HLAs] on donor cells' surface provoke immune response in recipient The donated organ / tissue can be damaged or “rejected” by the recipient's immune system Transplanting only ABO compatible grafts helps avoid ANTIBODY mediated rejection Transplanting organs that have (as nearly as possible) ...
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Document

... immune complex disease - serum sickness, Arthus reaction ...
Lesson 13 Class Notes I. Pathogens A. Bad bacteria 1. Single
Lesson 13 Class Notes I. Pathogens A. Bad bacteria 1. Single

... 1. def: body forms antibodies against its own tissue 2. allergies: B cells make antibodies against unharmful substances 3. antihistamines block inflammatory action 4. HIV: destroys helper T cells so can’t fight basic illnesses ...
Lymphatic system
Lymphatic system

... Antibodies – immunoglobulins (Igs)  Y shaped, 2 arms – light and heavy based on ...
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... Tolerance to a fetus The fetus is really an allograft with nonself MHC proteins & RBCs of the father so why is it not rejected by the mother? We know mothers’ makes antibodies against fathers’ MHC & RBC ...
Lymph Nodes
Lymph Nodes

... activated and mount attack against antigens ...
CHAPTER 16: LYMPHATIC SYSTEM AND IMMUNITY OBJECTIVES
CHAPTER 16: LYMPHATIC SYSTEM AND IMMUNITY OBJECTIVES

... Discuss the origin and maturation of lymphocytes. Stem cells in red bone marrow give rise to undifferentiated lymphocytes that are released into the blood. Those that reach the thymus are processed into T-Cells; those that are not processed by the thymus are most-likely processed in the fetal bone m ...
ABC Anatomy coloring book By: Britney Rac
ABC Anatomy coloring book By: Britney Rac

... Aorta is the largest artery in the body, the aorta arises from the left ventricle of the heart, goes up (ascends) a little ways, bends over (arches), then goes down (descends) through the chest and through the abdomen to where ends by dividing into two arteries called the common iliac arteries that ...


... Parts of the Immune System (cont.) • Hairs in your nose and hairlike structures called cilia trap pathogens in the upper respiratory system and move them out of your body. • The digestive system is effective at stopping pathogens that enter your body on or in the food you ...
PSYCHONEUROIMMUNOLOGY
PSYCHONEUROIMMUNOLOGY

... large east coast newspaper and astute lay person self-prescribed comedy films for reducing his own recovery time—Marx Brothers, Three Stooges, Candid Camera ...
Types II and III: Antibody-Mediated and Antigen
Types II and III: Antibody-Mediated and Antigen

... Systemic lupus erythematosus (SLE) is a long-term autoimmune disorder that may affect the skin, joints, kidneys, brain, and other organs. Causes, incidence, and risk factors Systemic lupus erythematosus (SLE) is an autoimmune disease, which means the body's immune system mistakenly attacks healthy t ...
The Generation of Diversity (GOD): How to Ensure
The Generation of Diversity (GOD): How to Ensure

... The T cell receptor heterodimer comprises two transmembrane glycoproteins, the alpha and beta chains. There are two domains in the external part of each chain and these resemble immunoglobulin variable and constant regions. There are sugar chains on each domain. There is a short sequence similar to ...
print version
print version

... protection. The second line of defence, the adaptive immune system, provides lifelong immunity; it “remembers” germs or cancers so that it can protect your body against similar attacks in the future. If the immune system is the cancer warrior, then T-cells are the key weapons in its arsenal. They at ...
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... Pathogens may influence the resulting adaptive immune response Science 302: 993-4; 2003 ...
T cells
T cells

... lymph nodes where B-cells proliferate Decreased immune surveillance by T lymphocytes and NK cells ...
Adaptive or Acquired Immunity
Adaptive or Acquired Immunity

... They cannot respond to viruses or bacteria unless they are attached to eukaryotic cells. There are three categories of T-cells involved in cellular immunity including; 1) ______________________________, CD4 lymphocytes that help B-cells respond to antigens and proliferate (they also cause other type ...
Systemic autoimmune diseases
Systemic autoimmune diseases

... • T cells bearing receptors for autoantigens escape into the periphery “ T cells slippage” • There is similar “slippage” in the B-cell system. • Cells slippage ______ Autoimmune Dis, or (+ve Auto Abs in the circulation) ...
Kuby Immunology 6/e - Dr. Jennifer Capers
Kuby Immunology 6/e - Dr. Jennifer Capers

... Severe Combined Immunodeficiency (SCID) ○ Low # of circulating lymphocytes ○ Non-proliferating T cells ○ Thymus doesn’t develop ...
finals_study_guide_2007_hazbun
finals_study_guide_2007_hazbun

... expressed simultaneously on a single cell) 5. How does one MHC molecule bind to approx. 10,000 different peptides? 6. What do we mean by MHC restriction? 7. Why can a haplotype be present at a high rate in a population and how might it protect against a specific disease? 8. How is a haplotype spread ...
Freeman 1e: How we got there
Freeman 1e: How we got there

... antigens that compose our body tissue. Thus, T cells must achieve tolerance, or specific unresponsiveness to self antigens. • The thymus is a primary lymphoid organ that provides an environment for the maturation of antigen-reactive T cells. ...
Lymphocyte T-Cell Immunomodulator (LTCI): Review of the
Lymphocyte T-Cell Immunomodulator (LTCI): Review of the

... Prior to 1960, the thymus gland was thought to be of little importance. In adult animals, the thymus is almost non-existent because it atrophies as animals reach adulthood. It was observed, however, that when pre-adolescent animals are thymectomized, they experience a variety of maladies including i ...
study_guide_2007_hazbun - Welcome to people.pharmacy
study_guide_2007_hazbun - Welcome to people.pharmacy

... b. diverse gene families (3 genes encode MHC I, 3 genes encode MHC II α chain and at least 3 genes encode MHC II β chain) c. expression of MHC is co-dominant (all genes of a given class (i.e., class I or class II) are expressed simultaneously on a single cell) 5. Exam II material commences from here ...
Course: Immunopathology and Immunotherapeutics
Course: Immunopathology and Immunotherapeutics

... • Course Contents: ...
Immune system
Immune system

... * Molecules of the immune system ...
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Thymus



The thymus is a specialized primary lymphoid organ of the immune system. Within the thymus, T cells or T lymphocytes mature. T cells are critical to the adaptive immune system, where the body adapts specifically to foreign invaders. The thymus is composed of two identical lobes and is located anatomically in the anterior superior mediastinum, in front of the heart and behind the sternum. Histologically, each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T-cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin (derived from bone marrow resident hematopoietic stem cells). Developing T-cells are referred to as thymocytes and are of hematopoietic origin. Stromal cells include epithelial cells of the thymic cortex and medulla, and dendritic cells.The thymus provides an inductive environment for development of T cells from hematopoietic progenitor cells. In addition, thymic stromal cells allow for the selection of a functional and self-tolerant T cell repertoire. Therefore, one of the most important roles of the thymus is the induction of central tolerance.The thymus is largest and most active during the neonatal and pre-adolescent periods. By the early teens, the thymus begins to atrophy and thymic stroma is mostly replaced by adipose (fat) tissue. Nevertheless, residual T lymphopoiesis continues throughout adult life.
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