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Tregs
Tregs

1 CAR-‐T Cell Therapy – Fact Sheet
1 CAR-‐T Cell Therapy – Fact Sheet

... How  are  the  CART-­‐T  cells  manufactured?     Because  CAR-­‐T  therapy  is  very  personalized  (it  requires  genetically  engineering  the  patient’s   own  T  cells)  there  is  considerable  infrastructure  and  expertise  required   ...
The main properties of cancer cell
The main properties of cancer cell

... loss-of function mutation, in cancer development. The P 53 gene is known to be the most important gene involved in all cancer. The final class of gene implicated in carcinogenesis is involved in the various DNA repair mechanisms that allow accurate DNA repair. One strategy tumors used to acquire ap ...
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The Clinical Research of Chimeric Antigen

... with antitumor CARs or TCRs, or a patient’s own cells can be modified with antitumor molecules. In the case of solid tumors,biopsy specimens can be used to isolate TILs for expansion. In most cases the patient will require some amount of conditioning before receiving antitumor lymphocyte infusions, ...
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杨海平The Clinical Research of Chimeric Antigen Receptor T

... with antitumor CARs or TCRs, or a patient’s own cells can be modified with antitumor molecules. In the case of solid tumors,biopsy specimens can be used to isolate TILs for expansion. In most cases the patient will require some amount of conditioning before receiving antitumor lymphocyte infusions, ...
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Cells of the innate immune system

... • Membrane bound: B cell’s antigen receptor (mIgG, mIgM) • Signalling to B cells (via Igα, Igβ) • Secreted antibodies by plasma cells, 109 different specificities! • 5 classes (isotypes: IgM, IgD, IgG, IgA, IgE) • Effector functions eliminate antigen ...
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Figure 1.1 The human immune system All blood cells originally

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Adoptive cell transfer

Adoptive cell transfer (ACT) is the transfer of cells into a patient; as a form of cancer immunotherapy. The cells may have originated from the patient him- or herself and then been altered before being transferred back, or, they may have come from another individual. The cells are most commonly derived from the immune system, with the goal of transferring improved immune functionality and characteristics along with the cells back to the patient. Transferring autologous cells, or cells from the patient, minimizes graft-versus-host disease (GVHD) or what is more casually described as tissue or organ rejection.
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