Lesson 13 Class Notes I. Pathogens A. Bad bacteria 1. Single
... b. B cells make special proteins called antibodies to grab specific antigen c. Antibody marks invader for killer T cells d. B and T cells remember invader to launch rapid, specific, aggressive response D. Autoimmune diseases 1. def: body forms antibodies against its own tissue 2. allergies: B cells ...
... b. B cells make special proteins called antibodies to grab specific antigen c. Antibody marks invader for killer T cells d. B and T cells remember invader to launch rapid, specific, aggressive response D. Autoimmune diseases 1. def: body forms antibodies against its own tissue 2. allergies: B cells ...
Presentation slides - Yale School of Medicine
... • most efficient of all APCs • high MHC class I, II & costimulators • efficient cross presentation • stimulate naïve T cells (CD4, CD8) initiate Ag-specific immune responses ...
... • most efficient of all APCs • high MHC class I, II & costimulators • efficient cross presentation • stimulate naïve T cells (CD4, CD8) initiate Ag-specific immune responses ...
The Immune System
... -T cells (cytotoxic & suppressor) -destroy infected cells -shut down response after pathogens are cleared 2. Humoral Immune Response -B cells change into plasma cells and produce antibodies. Antibodies – chemicals that binds to antigen to disable the pathogen (block reproduction). -Antigen specific ...
... -T cells (cytotoxic & suppressor) -destroy infected cells -shut down response after pathogens are cleared 2. Humoral Immune Response -B cells change into plasma cells and produce antibodies. Antibodies – chemicals that binds to antigen to disable the pathogen (block reproduction). -Antigen specific ...
The Selective p110 Inhibitor IPI-3063 Potently Suppresses B Cell
... The phosphoinositide-3-kinase (PI3K) signaling pathway is a crucial pathway that is involved in many cellular processes such as differentiation, proliferation and cell survival. The p110δ catalytic isoform of PI3K is critical for these cellular processes in B lymphocytes. Elevated PI3K signaling, ho ...
... The phosphoinositide-3-kinase (PI3K) signaling pathway is a crucial pathway that is involved in many cellular processes such as differentiation, proliferation and cell survival. The p110δ catalytic isoform of PI3K is critical for these cellular processes in B lymphocytes. Elevated PI3K signaling, ho ...
TCR rearrangement and selection in the thymus
... • Differentiate into high CD27 expressing DN3b cells and following pre-TCR selection lose CD25 expression • DN4 with surface expression of CD24, CD71 and CD98 and start to rearrange a chain • Diffentiate into DP (CD4+CD8+) cells where positive and ...
... • Differentiate into high CD27 expressing DN3b cells and following pre-TCR selection lose CD25 expression • DN4 with surface expression of CD24, CD71 and CD98 and start to rearrange a chain • Diffentiate into DP (CD4+CD8+) cells where positive and ...
immune response
... The rise in temperature causes an increase in the body's metabolic rate which allows the WBCs to function with greater efficiency. ...
... The rise in temperature causes an increase in the body's metabolic rate which allows the WBCs to function with greater efficiency. ...
TAKS Obj 2 -BIOLOGY
... inflammatory response (swelling, redness due to histamine release), fever, white blood cells such as phagocytes and macrophages destroying the pathogens and infected tissue cells. ...
... inflammatory response (swelling, redness due to histamine release), fever, white blood cells such as phagocytes and macrophages destroying the pathogens and infected tissue cells. ...
Supplementary Figure Legends (doc 28K)
... standard deviations. Significant P-values are indicated by asterisks (* P=0.03; ** P=0.003; *** P<0.001). (B) HLA-A2 molecule expression on the surfaces of MCF-7 and MDA-MB-231 cell lines. Immunofluorescence staining was performed using MA2.1 monoclonal antibody and analysed on BD LSR Flow Cytometer ...
... standard deviations. Significant P-values are indicated by asterisks (* P=0.03; ** P=0.003; *** P<0.001). (B) HLA-A2 molecule expression on the surfaces of MCF-7 and MDA-MB-231 cell lines. Immunofluorescence staining was performed using MA2.1 monoclonal antibody and analysed on BD LSR Flow Cytometer ...
1. dia - immunology.unideb.hu
... – benign: respecting tissue borders (basement membranes) – malignant: spread to all nearby tissues, can even give off metastases (local ones via the lymph, or distant ones via the blood) ...
... – benign: respecting tissue borders (basement membranes) – malignant: spread to all nearby tissues, can even give off metastases (local ones via the lymph, or distant ones via the blood) ...
How is a vaccine prepared?
... 4. Transplant Problems • Transplanted organs have foreign antigens on their cells because they come from another person. • Immune system recognizes antigens as foreign and attacks, causing rejection. • Transplant patients take drugs to reduce the effectiveness of their immune system, but as a resul ...
... 4. Transplant Problems • Transplanted organs have foreign antigens on their cells because they come from another person. • Immune system recognizes antigens as foreign and attacks, causing rejection. • Transplant patients take drugs to reduce the effectiveness of their immune system, but as a resul ...
Apoptosis – Programmed Cell Death
... cytoskeletal proteins and degradation of the inhibitor of caspase-activated DNase (ICAD). ...
... cytoskeletal proteins and degradation of the inhibitor of caspase-activated DNase (ICAD). ...
Document
... This system is activated when pathogens get past the general defence system Organs of the immune system that store WBC’s called lymphocytes and monocytes include the lymphatic vessels, tonsils, spleen lymph nodes ...
... This system is activated when pathogens get past the general defence system Organs of the immune system that store WBC’s called lymphocytes and monocytes include the lymphatic vessels, tonsils, spleen lymph nodes ...
Types of Immunoglobulins
... a. Can carry out almost all functions of Ig i. Opsonization Enhance phagocytosis ii. Antibody Dependent Cell-mediated Cytotoxicity (ADCC) Fab – Target cells (tumours/microbes) Fc – NK cells, so NK will release substance to destroy the target cells iii. Activation of Compliment system iv. Neutralizat ...
... a. Can carry out almost all functions of Ig i. Opsonization Enhance phagocytosis ii. Antibody Dependent Cell-mediated Cytotoxicity (ADCC) Fab – Target cells (tumours/microbes) Fc – NK cells, so NK will release substance to destroy the target cells iii. Activation of Compliment system iv. Neutralizat ...
A1979HZ32100001
... macrophages. While it was tempting to dismiss this as trivial, we made one further effort to produce the in vitro reaction, using more concentrated supernatants of antigen-stimulated lymphocytes. The results were striking in that the supernatant of antigen-stimulated sensitive lymphocytes was able t ...
... macrophages. While it was tempting to dismiss this as trivial, we made one further effort to produce the in vitro reaction, using more concentrated supernatants of antigen-stimulated lymphocytes. The results were striking in that the supernatant of antigen-stimulated sensitive lymphocytes was able t ...
Document
... lines of defense: anatomic barriers, the inflammatory response, and the immune response. The immune system has two anatomic components: the lymphoid tissues of the body and the cells that are responsible for the immune response. The primary cells of the immune system are the white blood cells, or le ...
... lines of defense: anatomic barriers, the inflammatory response, and the immune response. The immune system has two anatomic components: the lymphoid tissues of the body and the cells that are responsible for the immune response. The primary cells of the immune system are the white blood cells, or le ...
Spleen-thymus-09
... • Adults, mixture of epithelial cells and lymphocytes • Most (80%) encapsulated and histologically benign (benign thymoma) • Some (10%) similar histology but locally invasive (invasive thymoma; 75% 10-year survival) • Malignant thymoma (10%); histologically malignant, usually invasive, 25% 5-year su ...
... • Adults, mixture of epithelial cells and lymphocytes • Most (80%) encapsulated and histologically benign (benign thymoma) • Some (10%) similar histology but locally invasive (invasive thymoma; 75% 10-year survival) • Malignant thymoma (10%); histologically malignant, usually invasive, 25% 5-year su ...
Complexity and the Immune System
... But do we really need the network? • Genetic variation can lead to B and T cells that cover the entire range of pathogens, and each antibody hits on average one antigen • B cells differentiate into memory cells, which are able to quickly split into lots of effector cells and more memory cells • Aft ...
... But do we really need the network? • Genetic variation can lead to B and T cells that cover the entire range of pathogens, and each antibody hits on average one antigen • B cells differentiate into memory cells, which are able to quickly split into lots of effector cells and more memory cells • Aft ...
Cellular Communication
... – Immune cells interact by cell-cell contact, antigen presenting cells, helper T-cells and killer T-cells ...
... – Immune cells interact by cell-cell contact, antigen presenting cells, helper T-cells and killer T-cells ...
Immunology Notes
... activation of the immune system and maintain immune system homeostasis. Failure of regulatory T cells to function properly may result in autoimmune diseases in which the immunocytes attack healthy cells in the body. CD = Clusters of Differentiation Every effective immune response involves T cell act ...
... activation of the immune system and maintain immune system homeostasis. Failure of regulatory T cells to function properly may result in autoimmune diseases in which the immunocytes attack healthy cells in the body. CD = Clusters of Differentiation Every effective immune response involves T cell act ...
Team Publications
... Programmed Death-1 (PD-1), an inhibitory receptor expressed by activated lymphocytes, is involved in regulating T- and B-cell responses. PD-1 and its ligands are exploited by a variety of cancers to facilitate tumor escape through PD-1-mediated functional exhaustion of effector T cells. Here, we repo ...
... Programmed Death-1 (PD-1), an inhibitory receptor expressed by activated lymphocytes, is involved in regulating T- and B-cell responses. PD-1 and its ligands are exploited by a variety of cancers to facilitate tumor escape through PD-1-mediated functional exhaustion of effector T cells. Here, we repo ...