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Cell-mediated Response
Cell-mediated Response

... Cryptic Antigens: epitopes not presented for recognition by T cells unless they are produced in unusually large concentrations or are freed from their configuration in body. ...
What is the function of the Muscular System? What is the function of
What is the function of the Muscular System? What is the function of

... Lisa was not blindfolded and knew which plane she was throwing. Since she favors planes with winglets maybe she threw #1 harder without even realizing it. ...
A Timeline of Pioneering Cancer Treatment
A Timeline of Pioneering Cancer Treatment

... discovered by Louis Goodman. Nitrogen mustards, used in WWII chemical warfare, were found to be useful as chemotherapeutic agents against cancer. ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

... 6. Antibodies are classified based on the type of light chain they possess. 7. Major histocompatibility complex molecules inherited from both parents are codominantly expressed. 8. Myasthenia gravis is a systemic autoimmune disease. 9. A vaccine contains antibodies that stimulate adaptive immunity t ...
Cell Specialization
Cell Specialization

... Red blood cells form from undifferentiated cells in the bone marrow throughout your life. Bone marrow is the soft, interior portion of certain bones found in the chest, upper arms, upper legs and hips. The cells located here are undifferentiated, but limited in the type of cell they can become. They ...
Who Gets Lupus?
Who Gets Lupus?

... Sources of Autoantigens 1. Apoptotic cells 2. Activated cells (antigens move to cell membrane) 3. Modification of proteins during apoptosis 4. Infectious agents ...
Body in Action
Body in Action

PowerPoint Presentation - Atypical Cutaneous Leishmaniasis
PowerPoint Presentation - Atypical Cutaneous Leishmaniasis

... Release of sequestered antigens: Tissue ...
Dead cell-associated antigens
Dead cell-associated antigens

... ► Dead tumor cells in periphery accumulate in the draining lymph node sinus; ► CD169+ macrophages phagocytose and crosspresent dead cell-associated antigens; ► CD169+ macrophage-depleted mice fail to crossprime tumor-specific CD8 T cells; ► CD169+ macrophages link tumor cell death and induction of a ...
Respiratory tract
Respiratory tract

... physiologically sterile - it can cause the disease - is pathogenic (Escherichia coli - IF in colon - patogen in urinary tract) ...
Eman Mohamed Ali Hassan_Pathogenesis2
Eman Mohamed Ali Hassan_Pathogenesis2

... present antigens to T helper (CD4+ ) and T cytotoxic (CD8+) cells on major histocompatibility class I and II respectively (MHC-I& II). The T cells secrete interleukin 2 (IL-2) and at the same time express receptors for IL-2 on its cell surface. Interleukin-2 is a T cell growth factor necessary to su ...
Patterns_In_Nature
Patterns_In_Nature

... Cell theory was formulated over a period of about 300 years in parallel with the development of the microscope. Microscopes enabled scientists to make observations of tissues from organisms. As microscopes improved scientists began to study the internal structure of cells and ...
Physiology 2008
Physiology 2008

... i. nerve cell endings are directly damaged ii. as a consequence of fluid accumulation (edema) from the vessels with increased permeability c. pain, limitation of movement due to the edema, and tissue destruction all contribute to disturbance of function E. Tissue Repair - the substitution of viable ...
Theoretical Function of Hassall`s Corpuscles in the Thymus
Theoretical Function of Hassall`s Corpuscles in the Thymus

... ages ranging from 7 days to 12years old. In one experiment, they were removed from young cardiac patients and observed. Though the article does not mention it, the ages of the children they were taken from, as well as their immune condition resulting from their diseases may have been factors effecti ...
Chapter 22
Chapter 22

... 30. Discuss what response emerges if an antigen is small enough to instigate reactivity but not immunogenicity. Epitopes 31. Evaluate the capacity of segments of a pathogenic macromolecule to stimulate a reaction by specific B cells and T cells, and describe how this can lead to autoimmune responses ...
The Immune System
The Immune System

Anatomy and Physiology notes - Introduction, Cell
Anatomy and Physiology notes - Introduction, Cell

... synthesis of some important biomolecules Skin composed of two layers and underlying layer that attaches to deeper body: 6.2 1. epidermis - top layer that is exposed at surface - formed of stratified squamous epithelium - important cell types are keratinocytes (keratin producing cells) and melanocyte ...
Aptocine and Whole Cell Cancer Vaccines
Aptocine and Whole Cell Cancer Vaccines

... On the other hand, Aptocine can be used to treat tumor deposits with safer minimally invasive techniques in an outpatient fashion. Lesions ranging from 2cm to greater than 20cm have been effectively treated, multiple lesions have been treated in single sessions, and retreatment of large and multipl ...
T – lymphocytes J. Ochotná
T – lymphocytes J. Ochotná

Distinguished Visitor Programme
Distinguished Visitor Programme

... 13 Nov 2002 (Wed), 6.15-7.15 pm, Clinical Research Centre (CRC) Auditorium, Faculty of Medicine, MD 11, National University of Singapore, 10 Medical Drive, Singapore 117597 "Order from Disorder Sprung: Recognition and Regulation in the Immune System" "Milton's epic poem "Paradise Lost" supplies a co ...
Immunological investigation in Czech patients with
Immunological investigation in Czech patients with

... Czech Republic, Hungary, Slovenia, Croatia, Serbia, Russia. ...
T cell receptors, T cell function and signaling
T cell receptors, T cell function and signaling

... called Igα and Igβ, forming the BCR • The TCR is in a complex with invariant transmembrane proteins called CD3ε, δ, γ, and TCRζ • Igα, Igβ, CD3ε, CD3δ, CD3γ, and TCRζ each contain ITAM motifs • B cells express a co-receptor composed of CD21, CD18, and CD81 that binds complement, increasing B cell si ...
Basic Structure of the Human Body
Basic Structure of the Human Body

... 1. Nucleus: “brain” of cell; controls many cell activities, including production 2. Nucleolus: located in cell nucleus; important in reproduction (RNA) 3. Chromatin network: located in nucleus; forms chromosomes which contain genes that carry inherited characteristics; DNA (A-T/G-C bases); males XY ...
Pathophysiology of Lymphomas - Ipswich-Year2-Med-PBL-Gp-2
Pathophysiology of Lymphomas - Ipswich-Year2-Med-PBL-Gp-2

...  A mechanism (commonly EBV infection via LMP1)  NF-κB inhibitor mutation  act. Transcription factor NF-κB  act. Lymphocyte proliferation and survival genes  Theory: saves defective B cell from apoptosis, mutates to RS cell  RS secretes cytokines (IL-5,10,13, TNF-β) and chemokines calling react ...
Specific Immunity and Immunization
Specific Immunity and Immunization

... existing in the genetic makeup before an antigen has ever entered the tissues • Each genetically distinct lymphocyte expresses only a single specificity and can react to only one type of antigen ...
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Adoptive cell transfer

Adoptive cell transfer (ACT) is the transfer of cells into a patient; as a form of cancer immunotherapy. The cells may have originated from the patient him- or herself and then been altered before being transferred back, or, they may have come from another individual. The cells are most commonly derived from the immune system, with the goal of transferring improved immune functionality and characteristics along with the cells back to the patient. Transferring autologous cells, or cells from the patient, minimizes graft-versus-host disease (GVHD) or what is more casually described as tissue or organ rejection.
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