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Full Text  - Clinical Cancer Research
Full Text - Clinical Cancer Research

... Downloaded from clincancerres.aacrjournals.org on June 17, 2017. © 2014 American Association for Cancer Research. ...
11 Chronic Liver Disease Caitlyn M. Patrick, MD, and
11 Chronic Liver Disease Caitlyn M. Patrick, MD, and

... The patient with cirrhosis should receive preconception counseling. As part of this counseling, the physician should discuss the increased risks associated with pregnancy, optimize medical therapy to prevent fetal harm, address the risk for passage of the predisposing viral or genetic disease to the ...
Laboratory Diagnosis and Treatment of Hyperadrenocorticism in
Laboratory Diagnosis and Treatment of Hyperadrenocorticism in

... Canine hyperadrenocorticism (HAC) has been most commonly treated with the adrenolytic drug o, p'-DDD (mitotane). However, it is well recognised that mitotane has several side effects, is associated with a high frequency of relapses and is not without risk to owners. Other drugs such as ketoconazole ...
Ulcerative Colitis: Diagnosis and Treatment
Ulcerative Colitis: Diagnosis and Treatment

Hemoglobin concentration, total hemoglobin mass
Hemoglobin concentration, total hemoglobin mass

... hemoglobin synthesis or anemia of chronic inflammation; CLD patients may likewise lose blood, have an expanded circulating plasma volume due to hyperaldosteronism, or face fluid shifts as a result of raised portal venous pressure or hypoalbuminemia; and patients with chronic heart failure may suffer ...
Biology - WordPress.com
Biology - WordPress.com

... antibody levels in response to first and subsequent infections H 1.24 Describe the production of monoclonal antibodies, including: a use of B lymphocytes which produce desired antibodies but do not divide b production of hybridoma cells c hybridoma cells produce antibodies and they divide H 1.25 Dem ...
Annual Report 2014 - St. Jude Children`s Research Hospital
Annual Report 2014 - St. Jude Children`s Research Hospital

... Research in the Evans lab is focused on the pharmacogenomics of anticancer agents in children, with an emphasis on childhood acute lymphoblastic leukemia (ALL) (reviewed in Evans and Relling, Nature, 2004; Pui and Evans, NEJM, 2006; Paugh et al, Clin. Pharmacol. Ther. 2011). Several approaches are c ...
140
140

... from the immune system [12]. These viral peptides and/or tissue antigens altered by the virus may induce an atypical immune response. The concept of epitope spreading, whereby the tissue damage from a primary inflammatory process causes the release of previously sequestered antigen, leading to a sec ...
Serial Studies of Lung Volume and VA/Q, in Hyaline Membrane
Serial Studies of Lung Volume and VA/Q, in Hyaline Membrane

... validated. The respiratory exchange factor (R) is assumed for calculation of alveolar oxygen tension. The CO2 gradients are probably the least accurate and suffer from the limitation that a true end-tidal point cannot always be defined. However the 90% response time of 0.2 sec indicates that a large ...
An Investigation of Quality-of-Life Issues in Patient Treatment Using Enterprise Miner
An Investigation of Quality-of-Life Issues in Patient Treatment Using Enterprise Miner

... In a logistic regression, the same patient characteristics were statistically significant as given in the chi-square analysis in predicting the use of the treatment interferon. However, there is some question as to the appropriateness of the logistic regression because of the lack of independence of ...
B3 Topic 1 Revision tracker
B3 Topic 1 Revision tracker

... antibody levels in response to first and subsequent infections H 1.24 Describe the production of monoclonal antibodies, including: a use of B lymphocytes which produce desired antibodies but do not divide b production of hybridoma cells c hybridoma cells produce antibodies and they divide H 1.25 Dem ...
Commentary on application from WHO
Commentary on application from WHO

... with either treatment showed that the non-drugs costs associated with acyclovir are substantially greater than those with valaciclovir. Based on the clinical trial evidence provided, this is unlikely to be the case. The application states that there are no published studies of the cost-effectiveness ...
Developments in Cancer Treatments, Market Dynamics, Patient
Developments in Cancer Treatments, Market Dynamics, Patient

... spread rapidly than other types of breast cancer. ...
Patient-Centered Outcome Measures Initiatives in the
Patient-Centered Outcome Measures Initiatives in the

... should indicate disease progression and disease activity linked to a biological process and should assess any effects of therapeutic intervention.12,13 They can be used at all stages of drug development, from dose response to clinical efficacy endpoints, surrogate endpoints and long term drug respon ...
Concepts of Prevention and Control
Concepts of Prevention and Control

... irrespective of individual risk levels. • For example, studies have shown that even a small reduction in the average blood pressure or serum cholesterol of a population would produce a large reduction in the incidence of cardiovascular disease • The population approach is directed towards socio-econ ...
Pulse Intravenous Methylprednisolone as Adjunctive Treatment for
Pulse Intravenous Methylprednisolone as Adjunctive Treatment for

... The primary outcome measure was the proportion of patients achieving control of conjunctival inflammation in the study eye at 6 weeks. Control of conjunctival inflammation was defined as bulbar conjunctival inflammation grade 1.5 or less in all 4 quadrants, giving a total bulbar inflammation score o ...
Atopic Dermatitis Update
Atopic Dermatitis Update

... Adapted with permission from Gittler JK, Shemer A, Suarez-Farinas M, et al. Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol. 2012;130(6):1344-1354; with additional information from Leung DY, ...
Key Issues in Outcomes Research
Key Issues in Outcomes Research

... confirmed in other trials.15–18 However, not until 1996, more than a decade after the original publication of scientific evidence, did the American Heart Association/American College of Cardiology guidelines recommend the routine use of ␤-blockers for all eligible patients after acute myocardial inf ...
A Patient Report
A Patient Report

... accessing treatments for these patients. Frits Wijburg Metabolic Pediatrician and Professor at the Academic Medical Center in Amsterdam, The Netherlands During my career in metabolic diseases I have seen many patients with different metabolic disorders and I have learnt that NP-C is not only one of ...
Reviews/Testimonials - American Society of Health
Reviews/Testimonials - American Society of Health

... organised according to the way that clinicians think through clinical problems. The book is divided into three parts: anticoagulant medicines management, conditions requiring anticoagulant therapy and practical monitoring, and coagulation laboratory insights. In the first part, several chapters are ...
Anemia management in chronic kidney disease
Anemia management in chronic kidney disease

... known consequence of serious kidney disease. The evidence for this and the pioneering work of countless scientists that led to the recognition of kidneys as the controlling organs for red blood cell production in humans is beyond the scope of this paper. It should be pointed out, however, that befor ...
Phospholipase A2 levels in acute chest syndrome of sickle cell disease
Phospholipase A2 levels in acute chest syndrome of sickle cell disease

Department of Physical Therapy
Department of Physical Therapy

... drug administration, dose-response relationships, drug interactions, and factors influencing the effectiveness of medications are discussed. Students will answer clinical questions to distinguish the diverse classes of drugs as well as understand both practical and theoretical implications of drug u ...
Alpha -Antitrypsin (AAT) Deficiency: A guide to counseling patients
Alpha -Antitrypsin (AAT) Deficiency: A guide to counseling patients

... founded by individuals diagnosed with AAT deficiency. Its mission is to provide the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for alpha-1. This mission is achieved through the following programs and activities: The Alpha-1 Resea ...
Drugs and Lymphoedema: Those Which May Cause Oedema or
Drugs and Lymphoedema: Those Which May Cause Oedema or

... side effects are derived from placebo controlled clinical trials (in which a new drug is compared with an inactive one) or trials of one drug compared with another. The interpretation of the results of the former may be complicated by the fact that the illness for which the drug is used may cause oe ...
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Multiple sclerosis research

Treatments under investigation for multiple sclerosis may improve function, curtail attacks, or limit the progression of the underlying disease. Many treatments already in clinical trials involve drugs that are used in other diseases or medications that have not been designed specifically for multiple sclerosis. There are also trials involving the combination of drugs that are already in use for multiple sclerosis. Finally, there are also many basic investigations that try to understand better the disease and in the future may help to find new treatments.
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